Recombinant Human Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1, His-tagged
Cat.No. : | SERPINF1-5118H |
Product Overview : | Recombinant SERPINF1 protein containing a natural variant M72T was expressed in E. coli and purified by using conventional chromatography techniques. |
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Cat. No. : | SERPINF1-5118H |
Description : | PEDF, also known as SERPINF1, is an extracellular neurotrophic agent, first identified as a secreted product in conditioned medium from cultured fetal human retinal pigment epithelial (RPE) cells. It was reported that PEDF isolated from medium conditioned by human fetal RPE primary cultures promotes neurite outgrowth in cultured human retinoblastoma Y-79 cells. PEDF is also a member of the serpin family, a group of serine protease inhibitors. As PEDF does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
Concentration : | 0.5 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol. |
Purity : | > 85% by SDS - PAGE |
Sequence : | 20-418 amino acids: MGSSHHHHHH SSGLVPRGSH MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAH |
Molecular Mass : | 46.7 kDa (420 aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 [ Homo sapiens ] |
Official Symbol : | SERPINF1 |
Synonyms : | SERPINF1; EPC-1; PEDF; PIG35; pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SerpinF1; EPC1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigmentepithelium derived factor), member 1; pigment epithelium-derived factor; Serpin-F1; proliferation-inducing protein 35 |
Gene ID : | 5176 |
mRNA Refseq : | NM_002615 |
Protein Refseq : | NP_002606 |
MIM : | 172860 |
UniProt ID : | P36955 |
Chromosome Location : | 17p13.3 |
Function : | serine-type endopeptidase inhibitor activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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