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Active Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator)

Cat.No. : TNFRSF14-5144H
Product Overview : Recombinant human TNFRSF14 was expressed in Hi-5 Insect cells and purified by using conventional chromatography techniques.
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  • Gene Information
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Cat. No. : TNFRSF14-5144H
Description : HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a "receptor decoy" resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
Source : Human
Host : Hi-5 Insect cells
Form : Supplied as a lyophilized powder
Purity : >98% pure by SDS PAGE and HPLC
Sequence : Region of HVEM protein corresponding to amino acids LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRT
Endotoxin Levels : Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity : Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on Mouse L929 cells. The expected ED50 for this effect is 1.3-1.9 ug/ml of HVEM-Fc.
Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Storage : Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Homo sapiens ]
Official Symbol : TNFRSF14
Synonyms : TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; tumor necrosis factor receptor superfamily member 14; CD40-like protein; OTTHUMP00000000866; OTTHUMP00000204095; OTTHUMP00000204096; OTTHUMP00000204097; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Gene ID : 8764
mRNA Refseq : NM_003820
Protein Refseq : NP_003811
MIM : 602746
UniProt ID : Q92956
Chromosome Location : 1p36.3-p36.2
Pathway : Adaptive Immunity Signaling; Costimulation by the CD28 family; Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Herpes simplex infection; Immune System
Function : protein binding; receptor activity; tumor necrosis factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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