Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
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Recombinant Human IGFBP4 protein

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Cat.No.:
IGFBP4-5051H
Product Overview:
Recombinant Human IGFBP4 was expressed in Insect cells.
Description:
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells.
Source:
Insect cells
Species:
Human
Bio-activity:
Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
Molecular Mass:
Recombinant human IGF-BP4 is a 25.8 kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
AA Sequence:
DEAIHCPPC SEEKLARCR PPVGCEELV REPGCGCCA TCALGLGMP CGVYTPRCG SGLRCYPPR GVEKPLHTL MHGQGVCME LAEIEAIQE SLQPSDKDE GDHPNNSFS PCSAHDRRC LQKHFAKIR DRSTSGGKM KVNGAPRED ARPVPQGSC QSELHRALE RLAASQSRT HEDLYIIPI PNCDRNGNF HPKQCHPAL DGQRGKCWC VDRKTGVKL PGGLEPKGE LDCHQLADS FRE
Purity:
Above 95% as determined by SDS-PAGE Analysis.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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