Recombinant Human Fibroblast Growth Factor Receptor 3

• Cat.No.: FGFR3-5003H
• Product Overview: Recombinant human FGFR3 was expressed in Insect cells and purified by using conventional chromatography techniques.

Specification

• Cat. No.: FGFR3-5003H
• Description: Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known.
• Source: Human
• Host: Insect cells
• Form: Supplied as a lyophilized powder with no preservative. Reconstitute in sterile water to a concentration > 0.05mg/ml.
• Purity: >90% pure by SDS PAGE
• Molecular Mass: 170 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: <0.1 ng per g of sFGF-R3a
• Storage: Store at -70 deg C until reconstitution. Following reconstitution product should be aliquoted and frozen at -20 deg C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
• Official Symbol: FGFR3
• Synonyms: FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; OTTHUMP00000149958; OTTHUMP00000149959; tyrosine kinase JTK4; hydroxyaryl-protein kinase; achondroplasia, thanatophoric dwarfism; EC 2.7.10.1; FGFR-3; CD333 antigen
• Gene ID: 2261
• mRNA Refseq: NM_000142
• Protein Refseq: NP_000133
• MIM: 134934
• UniProt ID: P22607
• Chromosome Location: 4p16.3
• Pathway: Bladder cancer; Endocytosis; MAPK signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR
• Function: ATP binding; fibroblast growth factor receptor activity; identical protein binding; nucleotide binding; receptor activity; transferase activity