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Recombinant Human Collagen, Type XVIII, Alpha 1

Cat.No. : COL18A1-4986H
Product Overview : Recombinant human COL18A1 was expressed in E.coli and purified by using conventional chromatography techniques.
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  • Gene Information
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Cat. No. : COL18A1-4986H
Description : Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF basic.
Source : Human
Host : E.coli
Form : Supplied as a lyophilized powder.
Purity : >98% pure by SDS PAGE and HPLC
Sequence : Region of Endostatin protein corresponding to amino acids MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM
Molecular Mass : 20.2 kDa
Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Storage : Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ]
Official Symbol : COL18A1
Synonyms : COL18A1; collagen, type XVIII, alpha 1; KNO; KNO1; FLJ27325; FLJ34914; MGC74745; collagen alpha-1(XVIII) chain; endostatin; antiangiogenic agent; multi-functional protein MFP
Gene ID : 80781
mRNA Refseq : NM_030582
Protein Refseq : NP_085059
MIM : 120328
UniProt ID : P39060
Chromosome Location : 21q22.3
Pathway : Direct p53 effector; FOXA1 transcription factor network; Protein digestion and absorption
Function : extracellular matrix structural constituent; metal ion binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of COL18A1 in neurobiology, particularly its involvement in the central nervous system and potential implications for neurodegenerative disorders? 04/16/2021

COL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.

In angiogenesis, how does COL18A1 influence blood vessel formation, and what molecular mechanisms are involved in its regulation of endothelial cell behavior? 06/02/2020

COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.

What evidence supports the involvement of COL18A1 mutations in human diseases, and how do these mutations impact COL18A1 function and tissue homeostasis? 01/19/2019

Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.

How does COL18A1 contribute to the regulation of cellular senescence, and are there implications for age-related diseases and tissue degeneration? 12/30/2018

COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.

In cancer progression, how does COL18A1 influence tumor behavior, metastasis, and interactions with the tumor microenvironment? 08/11/2018

COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.

Customer Reviews (3)

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Reviews
06/01/2022

    The delivery was well-coordinated and timely.

    09/12/2019

      Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.

      12/23/2018

        The lab product showcases commendable quality.

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