Active Recombinant Human Defensin, Beta 4A
Cat.No. : | DEFB4A-037H |
Product Overview : | Recombinant human protein was expressed in E.coli and purified by using conventional chromatography techniques. |
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- Gene Information
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Cat. No. : | DEFB4A-037H |
Description : | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. |
Source : | Human |
Host : | E.coli |
Form : | Supplied lyophilized with no additives. Reconstitute in 10 mM Acetic Acid to a concentration of 0.1 - 1.0 mg/ml. |
Purity : | >98% pure by SDS PAGE and HPLC |
Sequence : | Region of BD2 protein corresponding to amino acids GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P. |
Molecular Mass : | 4.3 kDa |
Applications : | Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions |
Endotoxin Levels : | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
Bioactivity : | Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml. |
Storage : | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | DEFB4A defensin, beta 4A [ Homo sapiens ] |
Official Symbol : | DEFB4A |
Synonyms : | DEFB4A; SAP1; DEFB2; DEFB4; HBD-2; DEFB-2; DEFB102; BD-2; DEFB4B; hBD-2; defensin, beta 4A; beta-defensin 4A; defensin, beta 2; defensin, beta 4; OTTHUMP00000159651; skin-antimicrobial peptide 1; Beta-defensin 2 |
Gene ID : | 1673 |
mRNA Refseq : | NM_004942 |
Protein Refseq : | NP_004933 |
MIM : | 602215 |
UniProt ID : | O15263 |
Chromosome Location : | 8p23.1 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionDEFB4A has a typical β-defensin structure consisting of a cysteine-rich mature peptide region and a positively charged N-terminal region. This structure allows it to bind and destroy the cell membranes of pathogenic microorganisms.
Biomolecules that can be used as molecular markers for DEFB4A include its mRNA and protein expression products in tissues and cells, as well as other biomolecules (e.g., receptors, signal transduction molecules, etc.) that interact with it.
The abnormal expression of DEFB4A is associated with a variety of inflammatory and infectious diseases, such as psoriasis, atopic dermatitis, chronic sinusitis, etc. In addition, the expression of DEFB4A has also been found to be associated with the occurrence and progression of certain tumors.
Therapeutic strategies for DEFB4A include modulating its expression levels, enhancing its antimicrobial activity, and developing inhibitors targeting its signaling pathway. Treatment depends on the type and severity of the disease.
The mRNA and protein expression levels of DEFB4A in tissues and cells can be detected by real-time PCR, immunohistochemistry, and western blotting.
There are interactions between DEFB4A and other biomolecules. For example, it can bind to the cell membrane of pathogenic microorganisms and disrupt their integrity to exert antimicrobial effects, and it can also bind to receptors on the surface of epithelial cells to activate signal transduction pathways and regulate cellular immune responses.
Customer Reviews (3)
Write a reviewThe structure is very stable and not easy to deteriorate.
The cost is low and the activity is strong, which greatly saves our scientific research costs.
The quality of the DEFB4A is very high, which makes my experiments more smooth and accurate.
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