Recombinant Human BMP6

• Cat.No.: BMP6-41H
• Product Overview: Recombinant human BMP6 protein was expressed in HEK293 Cells and purified by using conventional chromatography techniques.

Specification

• Cat. No.: BMP6-41H
• Description: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown.
• Source: HEK 293 cells
• Species: Human
• Predicted Molecular Mass: 26.2 kDa
• Amino Acid Sequence: Region of BMP6 protein corresponding to amino acids VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH.
• Formulation: Lyophilized from 10mM Tris, pH 9.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Purity: >95% pure by SDS PAGE and HPLC
• Endotoxin Level: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.
• Applications: SDS-PAGE
• Stability & Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: BMP6 bone morphogenetic protein 6 [ Homo sapiens ]
• Official Symbol: BMP6
• Synonyms: BMP6; bone morphogenetic protein 6; VGR; VG; vegetal related growth factor (TGFB- related); Bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1
• Gene ID: 654
• mRNA Refseq: NM_001718
• Protein Refseq: NP_001709
• MIM: 112266
• UniProt ID: P22004
• Chromosome Location: 6p24-p23
• Pathway: Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity; protein binding