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Recombinant Human Pegylated Interferon Alpha-2b

Cat.No. : IFNA2-05H
Product Overview : Recombinant Human Interferon alpha-2b produced inE. coliis a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19269 Dalton. Pegylated IFN alpha-2b is manufactured by attaching a 40KD NHS-mPEG to the primary amino acid of IFN alpha-2b.
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Cat. No. : IFNA2-05H
Description : At least 23 different variants of IFN-alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end.
Purity : >98% as determined by SDS-PAGE , RP-HPLC and FPLC.
Formulation : Lyophilized from a (0.5mg/ml) solution in containing 8.8mg sodium chloride, 0.4mg sodium acetate and 1.0mg acetate acid buffer.
Specific Activity : The specific activity as determined in a viral resistance assay using VSV-WISH cells was found to be 1.0 x 106IU/mg.
Endotoxin : Less than 0.1 ng/µg (IEU/µg) of PEG-IFN alpha-2b.
Reconstitution : It is recommended to reconstitute the lyophilized PEG-IFN alpha-2b in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage : Lyophilized PEG-IFN alpha-2b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEG-IFN alpha-2b should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.
Gene Name : IFNA2
Synonyms : IFNA; INFA2; MGC125764; MGC125765; Leukocyte interferon; B cell interferon, Type I interferon; IFNA2; IFN-α2a; Interferon alpha-A; LeIF A; Interferon alpha-2; Interferon alpha-2 Precursor; interferon, alpha 2
Gene ID : 3440
mRNA Refseq : NM_000605.2
Protein Refseq : NP_000596.2
MIM : 147562
UniProt ID : P01563
Chromosome Location : 9p22
Pathway : Antigen processing and presentation; Cytokine-cytokine receptor interaction ;Jak-STAT signaling pathway ;KEGG pathway: Natural killer cell mediated cytotoxicity ;Regulation of autophagy ;Toll-like receptor signaling pathway
Function : interferon-alpha/beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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