Recombinant Human Interleukin-11
Cat.No. : | IL11-19H |
Product Overview : | The protein is produced inP. Pichiaby recombinant DNA technology. The protein has a molecular mass of approximately 19,000 Daltons and is non-glycosylated. The protein is 177 amino acids in length and differs from the 178 amino acid length of native IL-11 only in lacking the amino-terminal praline residue. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL11-19H |
Description : | IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 is a member of a family of human growth factors which includes human growth hormone, granulocyte colony-stimulating factor and other growth factors. |
Purity : | >95% as determined by SDS-PAGE and SEC-HPLC. |
Formulation : | The protein was lyophilized from a concentrated (1mg/ml) solution with no additives. |
Specific Activity : | The ED50 as determined by the dose-dependant stimulation of the proliferation of murine 7TD1 was found to be less than 0.2ng/ml, corresponding to a Specific Activity of 8.0 x 106IU/ mg. |
Endotoxin : | Less than 2ng/mg (2IEU/mg) determined by LAL test. |
Reconstitution : | It is recommended to reconstitute the lyophilized rHuIL-11 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Storage : | Lyophilized rHuIL-11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles. |
Gene Name : | IL11 |
Synonyms : | AGIF; IL-11; Adipogenesis inhibitory factor, Oprelvekin, Interleukin-11; IL11; interleukin 11 |
Gene ID : | 3589 |
mRNA Refseq : | NM_000641 |
Protein Refseq : | NP_000632 |
MIM : | 147681 |
UniProt ID : | P20809 |
Chromosome Location : | 19q13.3-q13.4 |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | cytokine activity, interleukin-11 receptor binding activity |
Products Types
◆ Recombinant Protein | ||
IL11-061H | Active Recombinant Human IL11 Protein | +Inquiry |
IL11-2289H | Recombinant Human IL11 Protein, His-tagged | +Inquiry |
Il11-138M | Recombinant Active Mouse IL11 Protein, His-tagged(N-ter) | +Inquiry |
Il11-46M | Active Recombinant Mouse Il11 Protein (Pro22-Leu199), N-His tagged, Animal-free, Carrier-free | +Inquiry |
IL11-1305C | Recombinant Cynomolgus IL11 protein(Phe22-Leu199) | +Inquiry |
◆ Lysates | ||
IL11-5249HCL | Recombinant Human IL11 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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