Recombinant Human CD80 Molecule, Fc-Tagged
Cat.No. : | CD80-54H |
Product Overview : | Recombinant Human CD80 Molecule, Fc-Tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 455 amino acids and predicts a molecular mass of 51.7 KDa. By SDS-PAGE, the apparent molecular mass of rh B7-1/Fc is approximately 80-90 KDa due to the glycosylation. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CD80-54H |
Description : | B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulateT- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. A DNA sequence encoding the extracellular domain ( Met 1- Asn 242 ) of human B7-1 (NP_005182.1) precursor was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus. |
Predicted N terminal : | Val 35 |
Purity : | > 95%, as determined by SDS-PAGE |
Endotoxin : | < 1.0 EU per 1μg cytokine as determined by the LAL method |
Formulation : | Supplied as a 0.2μm filtered solution of PBS, pH7.4 |
Reconstitution : | Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Stability : | Samples are stable for up to twelve months from date of receipt -70°C |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles. |
Gene Name : | CD80 |
Synonyms : | CD28LG; CD28LG1; LAB7; B7; BB1; B-lymphocyte activation antigen B7; CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; Activation B7-1 antigen;CD80; CD80 molecule |
Gene ID : | 941 |
mRNA Refseq : | NM_005191 |
Protein Refseq : | NP_005182 |
MIM : | 112203 |
UniProt ID : | P33681 |
Chromosome Location : | 3q13.3-q21 |
Pathway : | Cell adhesion molecules (CAMs);Toll-like receptor signaling pathway; Type I diabetes mellitus |
Function : | coreceptor activity; protein binding; transcription activator activity. |
Products Types
◆ Recombinant Protein | ||
Cd80-24R | Recombinant Rat Cd80 Protein, His (Fc)-Avi-tagged | +Inquiry |
Cd80-36M | Recombinant Mouse CD80 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
Cd80-10528M | Recombinant Mouse Cd80 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD80-591M | Recombinant Mouse CD80 Protein, Fc-tagged | +Inquiry |
CD80-586C | Recombinant Cynomolgus monkey CD80 Protein | +Inquiry |
◆ Lysates | ||
CD80-948CCL | Recombinant Cynomolgus CD80 cell lysate | +Inquiry |
CD80-2715HCL | Recombinant Human CD80 cell lysate | +Inquiry |
CD80-1767MCL | Recombinant Mouse CD80 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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