Recombinant Human Ubiquitin Conjugating Enzyme 7
Cat.No. : | UBE2G1-09H |
Product Overview : | Ubiquitin Conjugating enzyme 7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 154 amino acids & having a molecular mass of 17.9 kDa. |
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- Gene Information
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Cat. No. : | UBE2G1-09H |
Description : | Human Ubquitin-conjugating enzyme 7 (UbcH7) is a ubiquitin-conjugating enzyme (E2) mediating c-fos degradation, transcription factor NF-B maturation, and human papilloma virus-mediated p53 and Myc protein degradation, in vitro. The ubiquitin-conjugating enzymes (E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. The human UBE2L1-UBE2L4 gene could potentially encode different isoforms of the UbcH7. UBE2L3 gene, located at chromosome 22q11.2, is the only identical family member with introns and encodes a polypeptide sequence identical to that of UbcH7 |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile filtered colorless solution. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein (1 mg/ml) contains 50mM HEPES (pH-7.5) 150mM NaCl, 1mM DTT, and 10% glycerol. |
Stability : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
Gene Name : | UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) [ Homo sapiens ] |
Synonyms : | UBE2G1; E217K; UBC7; UBE2G; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); UBC7; E217K; UBE2G; UBE2G1; ubiquitin-conjugating enzyme E2G 1; ubiquitin-protein ligase G1; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7); EC 6.3.2.19; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1; ubiquitin-conjugating enzyme E2G; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast). |
Gene ID : | 7326 |
mRNA Refseq : | NM_003342 |
Protein Refseq : | NP_003333 |
MIM : | 601569 |
UniProt ID : | P62253 |
Chromosome Location : | 1q42; 17p13.2 |
Function : | ligase activity; ubiquitin-protein ligase activity. |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that UBE2G1 may be associated with the onset of cardiovascular diseases such as atherosclerosis and myocardial infarction.
Drug development for UBE2G1 is currently in clinical trials, including small molecule inhibitors against UBE2G1 and inhibitors against the UBE2G1 signaling pathway.
There is no direct way to increase the expression level of UBE2G1, but it can be improved by regulating gene expression and providing nutritional support.
Studies have shown that UBE2G1 can be involved in the regulation of antiviral immune responses and affect the course of viral infection.
UBE2G1 plays an important role in the pathogenesis of certain autoimmune diseases.
In clinical practice, the expression level of UBE2G1 can be measured to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of cancer, measuring the expression level of UBE2G1 can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment plan.
Customer Reviews (3)
Write a reviewThe experimental results using UBE2G1 are accurate and reliable, and the data are highly scientific.
UBE2G1 has high yield and good economic benefits.
The price is reasonable and the quality is very good. I'm very satisfied.
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