Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Trefoil Factor 1

Cat.No. : TFF1-86H
  • Specification
  • Gene Information
  • Related Products
Cat. No. : TFF1-86H
Description : Recombinant Human Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene.
Source : Escherichia coli.
Molecular Weight : 13.2 kDa homodimeric protein consisting of two 60 amino acid polypeptide chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Purity : >97% by SDS-PAGE and HPLC analyses.
Biological Activity : Fully biologically active when compared to standard.Determined by its ability to activate ERK1/2 (a MAPkinase signaling molecule) using a concentration 1.0-2.0 μg/ml.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.
Endotoxin : Less than 1EU/μg of rHuOTOR as determined by LAL method.
AA Sequence : EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage : This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name : TFF1 trefoil factor 1 [ Homo sapiens ]
Synonyms : TFF1; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2; trefoil factor 1; gastrointestinal trefoil protein pS2; breast cancer estrogen-inducible sequence; Breast cancer estrogen-inducible protein; breast cancer, estrogen-inducible sequence expressed in gastrointestinal trefoil protein pS2; pS2 protein; trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancer cell line M.
Gene ID : 7031
mRNA Refseq : NM_003225
Protein Refseq : NP_003216
MIM : 113710
UniProt ID : P04155
Chromosome Location : 21q22.3
Function : growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there targeted therapies based on FGFR3 in cancer treatment? 01/22/2021

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

What clinical applications are there for FGFR3 in cancer diagnosis? 10/14/2020

FGFR3 testing can aid in diagnosing specific types of cancer, especially bladder cancer, where FGFR3 mutations are prevalent.

How is FGFR3 targeted in cancer therapy? 06/06/2020

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

How is FGFR3 associated with cancer? 11/21/2018

Mutations in the FGFR3 gene can lead to the development of certain cancers, including bladder cancer and multiple myeloma.

Is FGFR3 testing routinely conducted in cancer diagnosis? 02/24/2018

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Customer Reviews (3)

Write a review
Reviews
08/18/2022

    TFF1 protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.

    11/01/2020

      Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.

      07/28/2017

        Scientists who have employed TFF1 protein in their experiments have praised its outstanding performance and reliability.

        Ask a Question for All TFF1 Products

        Required fields are marked with *

        My Review for All TFF1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends