Recombinant Human Trefoil Factor 1
Cat.No. : | TFF1-86H |
- Specification
- Gene Information
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Cat. No. : | TFF1-86H |
Description : | Recombinant Human Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF1 is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene. |
Source : | Escherichia coli. |
Molecular Weight : | 13.2 kDa homodimeric protein consisting of two 60 amino acid polypeptide chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. |
Purity : | >97% by SDS-PAGE and HPLC analyses. |
Biological Activity : | Fully biologically active when compared to standard.Determined by its ability to activate ERK1/2 (a MAPkinase signaling molecule) using a concentration 1.0-2.0 μg/ml. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation : | Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl. |
Endotoxin : | Less than 1EU/μg of rHuOTOR as determined by LAL method. |
AA Sequence : | EAQTETCTVA PRERQNCGFP GVTPSQCANK GCCFDDTVRG VPWCFYPNTI DVPPEEECEF |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions. |
Storage : | This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles. |
Gene Name : | TFF1 trefoil factor 1 [ Homo sapiens ] |
Synonyms : | TFF1; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2; trefoil factor 1; gastrointestinal trefoil protein pS2; breast cancer estrogen-inducible sequence; Breast cancer estrogen-inducible protein; breast cancer, estrogen-inducible sequence expressed in gastrointestinal trefoil protein pS2; pS2 protein; trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancer cell line M. |
Gene ID : | 7031 |
mRNA Refseq : | NM_003225 |
Protein Refseq : | NP_003216 |
MIM : | 113710 |
UniProt ID : | P04155 |
Chromosome Location : | 21q22.3 |
Function : | growth factor activity |
Products Types
◆ Recombinant Protein | ||
TFF1-1537H | Recombinant Human TFF1 Protein (25-84 aa), His-tagged | +Inquiry |
Tff1-6379M | Recombinant Mouse Tff1 Protein, Myc/DDK-tagged | +Inquiry |
TFF1-050T | Active Recombinant Human TFF1 Protein | +Inquiry |
TFF1-3568H | Recombinant Human TFF1, His-tagged | +Inquiry |
TFF1-1142H | Recombinant Human TFF1 Protein (Met1-Phe84), His-tagged | +Inquiry |
◆ Lysates | ||
TFF1-1127HCL | Recombinant Human TFF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.
FGFR3 testing can aid in diagnosing specific types of cancer, especially bladder cancer, where FGFR3 mutations are prevalent.
FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.
Mutations in the FGFR3 gene can lead to the development of certain cancers, including bladder cancer and multiple myeloma.
FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.
Customer Reviews (3)
Write a reviewTFF1 protein is highly recommended for scientific research applications, especially in ELISA assays and protein electron microscopy structure analysis.
Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.
Scientists who have employed TFF1 protein in their experiments have praised its outstanding performance and reliability.
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