Recombinant Human SCLY, His-tagged

• Cat.No.: SCLY-7952H
• Product Overview: Recombinant Human Selenocysteine Lyase/SCLY is produced by our E. coli expression system. The target protein is expressed with sequence (Met1Ala445) of Human SCLY fused with a 6His tag at the Nterminus.

Specification

• Description: Selenocysteine Lyase belongs to the classV pyridoxalphosphatedependent aminotransferase family. Selenocysteine Lyase exists as a homodimer in the cytosol. In the brain, Selenocysteine Lyase is as an enzyme that putatively salvages Sec and recycles the selenium for selenoprotein translation. Selenocysteine Lyase catalyzes the decomposition of Lselenocysteine to Lalanine and elemental selenium. Selenocysteine Lyase can be upregulated In acute glomerulonephritis, it can also be regulated by JUN/AP1.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μM filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Store at less than 20°C. stable for 6 months after receipt.Please minimize freezethaw cycles.

Gene Information

• Gene Name: SCLY selenocysteine lyase [ Homo sapiens ]
• Official Symbol: SCLY
• Synonyms: SCLY; selenocysteine lyase; putative selenocysteine lyase; SCL; hSCL
• Gene ID: 51540
• mRNA Refseq: NM_016510
• Protein Refseq: NP_057594
• MIM: 611056
• UniProt ID: Q96I15
• Chromosome Location: 2q37.3
• Pathway: Metabolic pathways, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenocompound metabolism, organism-specific biosystem; Selenocompound metabolism, conserved biosystem
• Function: lyase activity; pyridoxal phosphate binding; selenocysteine lyase activity; transferase activity