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Native Human Serum Alpha 1-AntiChymoTrypsin

Cat.No. : SERPINA3-8008H
Product Overview : Human Serum Alpha 1-AntiChymoTrypsin was purified from Human Serum.
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  • Gene Information
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Description : Human Alpha 1 antichymotrypsin (Alpha 1-ACT) (ACT)is an alpha globulin glycoprotein and serpin. This Human Glycoprotein is found in alpha(1)-globulin region in human serum. Human Alpha 1-antichymotrypsin (ACT)(Alpha 1-ACT) inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. Human Alpha 1-antichymotrypsin (ACT)(Alpha 1-ACT) also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. Human Alpha 1-antichymotrypsin (ACT)(Alpha 1-ACT) is a member of the serpin superfamilyHuman Alpha 1-antichymotrypsin (Alpha 1-ACT) (ACT)can complex with human PSA to form human PSA-ACT complex which is used as an indicator of tumour mass and clinical stage of prostate cancer
Source : Human Serum
Species : Human
Form : Lyophilized from 0.02M Tris buffer, pH 7.5 containing 0.15M NaCl
Molecular Mass : 68 kDa
Purity : >90% by SDS-PAGE
Stability : 2 years
Storage : 2-8 °C
Gene Name : SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 [ Homo sapiens ]
Official Symbol : SERPINA3
Synonyms : SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; AACT, alpha 1 antichymotrypsin , serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3; alpha-1-antichymotrypsin;
Gene ID : 12
mRNA Refseq : NM_001085
Protein Refseq : NP_001076
MIM : 107280
UniProt ID : P01011
Chromosome Location : 14q32.1
Pathway : Selenium Pathway, organism-specific biosystem;
Function : DNA binding; peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the physiological roles of Serpina3n? 10/13/2022

Serpina3n plays significant roles in various physiological processes, including modulation of the complement cascade, apoptosis, wound healing, and potential implications in Alzheimer's disease.

What is the significance of Serpina3n in pathologies? 03/31/2022

Recent studies have reported significant roles of Serpina3n during various pathologies, particularly in central nervous system (CNS) insults, making it a potential therapeutic target.

What is the aim of literature drawing together Serpina3n applications? 03/26/2021

The aim is to compile literature shedding light on the potential therapeutic applications of Serpina3n/SERPINA3 in various diseases. Additionally, a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) is provided to account for their biological roles and significance.

Are the full range of Serpina3n applications known? 07/21/2020

The full range of potential applications of Serpina3n is yet to be fully revealed, but its reported implications, especially in CNS insults, suggest potential therapeutic applications.

What is Serpina3n? 05/06/2020

Serpina3n is a secretory serine protease inhibitor belonging to clade "a" with unique structural and physiological characteristics. |

How does Serpina3n inhibit proteases? 05/12/2017

Serpina3n inhibits a wide range of proteases, contributing to its diverse physiological roles.

To which clade does Serpina3n belong? 03/07/2016

Serpina3n belongs to clade "a" of serine protease inhibitors. |

Customer Reviews (3)

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Reviews
03/14/2022

    The product's impact extended to data analysis, with intuitive tools for interpreting experimental results.

    06/14/2020

      The longevity of the product's effects allowed us to study cellular responses over extended timeframes.

      10/31/2017

        We found that the product's support for data analysis and visualization significantly expedited our research.

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