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Native Human Serum Alpha 2 MacroGlobulin

Cat.No.: A2M-8019H
Product Overview: Human Serum Alpha 2 MacroGlobulin was purified from Human Serum.
Description: Human Alpha-2-macroglobulin(A2M)is a large plasma protein found in the blood. Human Alpha-2-macroglobulin (A2M) is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.Human Alpha-2-macroglobulin(A2M)levels are increased in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins.
Source: Human Serum
Species: Human
Form: Lyophilized from 0.02M Tris, 0.15M NaCl
Molecular Mass: 650-800 kDa
Purity: >96% by SDS-PAGE
Stability: 1 year
Storage: 2-8 °C
Concentration: Typically >1.0 mg/mL (dispensing solution)
Gene Name: A2M alpha-2-macroglobulin [ Homo sapiens ]
Official Symbol: A2M
Synonyms: A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2MD; S863-7; DKFZp779B086;
Gene ID: 2
mRNA Refseq: NM_000014
Protein Refseq: NP_000005
MIM: 103950
UniProt ID: P01023
Chromosome Location: 12p13.31
Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem;
Function: enzyme binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; protein binding; serine-type endopeptidase inhibitor activity; tumor necrosis factor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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