Native Human ApoLipoprotein CIII

• Cat.No.: APOC3-8040H
• Product Overview: Human Apo-CIII is purified from delipidated VLDL(very low density lipoprotein). Impurities removed by affinity chromotography.

Specification

• Description: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
• Source: Human Plasma
• Species: Human
• Form: 75 mM PBS, 0.5 mM EDTA, pH 7.2
• Molecular Mass: 8.75 kDa
• Purity: >99% by SDS-PAGE
• Storage: -20 °C Avoid repeat freezing and thawing

Gene Information

• Gene Name: APOC3 apolipoprotein C-III [ Homo sapiens ]
• Official Symbol: APOC3
• Synonyms: APOC3; apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; HALP2; APOCIII; MGC150353
• Gene ID: 345
• mRNA Refseq: NM_000040
• Protein Refseq: NP_000031
• MIM: 107720
• UniProt ID: P02656
• Chromosome Location: 11q23-qter
• Pathway: Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem
• Function: cholesterol binding; enzyme regulator activity; high-density lipoprotein particle receptor binding; lipase inhibitor activity; phospholipid binding