Active Native Human CKB protein

• Cat.No.: CKB-8079H
• Product Overview: Native Human CKB was purified in Human Brain.

Specification

• Description: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
• Source: Human Brain
• Species: Human
• Form: 50% Glycerol, 25 mM Imidazole, 1 mM DTE, pH 6.5.
• Bio-activity: > 500 U/mL (Dimension® Clinical Chemistry System)
• Unit Definition: One unit will transfer one micromole of phosphate from creatine phosphate to ADP per minute at 37 centigrade
• Storage: Store at -20 centigrade.
• Concentration: > 0.5 mg protein/mL (Coomassie)

Gene Information

• Gene Name: CKB creatine kinase, brain [ Homo sapiens ]
• Official Symbol: CKB
• Synonyms: CKB; creatine kinase, brain; CKBB; creatine kinase B-type; creatine kinase-B; creatine kinase B chain; B-CK
• Gene ID: 1152
• mRNA Refseq: NM_001823
• Protein Refseq: NP_001814
• MIM: 123280
• UniProt ID: P12277
• Chromosome Location: 14q32.32
• Pathway: Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Creatine metabolism, organism-specific biosystem; Creatine pathway, organism-specific biosystem; Creatine pathway, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: ATP binding; creatine kinase activity; nucleotide binding