Native Human Neutrophil Elastase

• Cat.No.: ELANE-8104H
• Product Overview: Human Neutrophil Elastase was purified from Human Neutrophil.

Specification

• Description: Human Neutrophils, also known as neutrophilic polymorphonuclear leukocytes, are the major class of white blood cell in human peripheral blood. Human Neutrophil(s), have a multilobed nucleus and neutrophilic granules. Neutrophil(s) are phagocytes and have an important role in engulfing and killing extracellular pathogens.Neutrophil elastase (NE) is a key enzyme for tissue injury caused by activated neutrophils, such as occurs in Acute Lung injury.The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains.
• Source: Human Neutrophil
• Species: Human
• Form: 50 mM sodium acetate, pH 5.5, 0.6 M sodium chloride
• Purity: >90% by SDS-PAGE
• Stability: 1 year
• Storage: 2-8 °C
• Concentration: Typically >1 mg/mL

Gene Information

• Gene Name: ELANE elastase, neutrophil expressed [ Homo sapiens ]
• Official Symbol: ELANE
• Synonyms: ELANE; elastase, neutrophil expressed; ELA2, elastase 2, neutrophil; neutrophil elastase; HLE; HNE; leukocyte elastase; medullasin; NE; elastase-2; PMN elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow se
• Gene ID: 1991
• mRNA Refseq: NM_001972
• Protein Refseq: NP_001963
• MIM: 130130
• UniProt ID: P08246
• Chromosome Location: 19p13.3
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem
• Function: bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protease binding; protein binding; serine-type endopeptidase activity