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Recombinant Human POLE3, His-tagged

Cat.No. : POLE3-7630H
Product Overview : Recombinant human POLE3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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Description : POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging. POLE3 has been shown to interact with SMARCA5.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 1mM DTT.
Molecular Mass : 19kDa (170aa)
Protein length : 1-147aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMAERPED LNLPNAVITR IIKEALPDGV NISKEARSAI SRAASVFVLY ATSCANNFAM KGKRKTLNAS DVLSAMEEME FQRFVTPLKE ALEAYRREQK GKKEASEQKK KDKDKKTDSE EQDKSRDEDN DEDEERLEEE EQNEEEEVDN
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml
Gene Name : POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) [ Homo sapiens ]
Official Symbol : POLE3
Synonyms : POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit); DNA polymerase epsilon subunit 3; arsenic transactivated protein; CHARAC17; CHRAC17; chromatin accessibility complex 17; DNA polymerase epsilon p17 subunit; histone fold protein CHRAC17; p17; Ybl1; asTP; CHRAC-17; huCHRAC17; DNA polymerase II subunit 3; arsenic-transactivated protein; DNA polymerase epsilon subunit p17; chromatin accessibility complex 17 kDa protein; YBL1;
Gene ID : 54107
mRNA Refseq : NM_017443
Protein Refseq : NP_059139
MIM : 607267
UniProt ID : Q9NRF9
Chromosome Location : 9q33
Pathway : Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA polymerase epsilon complex, organism-specific biosystem; DNA replication, organism-specific biosystem; DNA replication, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function : DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; sequence-specific DNA binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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