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Recombinant Human ADAMTS4, GST-tagged

Cat.No. : ADAMTS4-536H
Product Overview : Recombinant Human ADAMTS4 (693 a.a. - 802 a.a.) fused with GST-tag at N-terminal, was expressed in vitro wheat germ expression system.
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Cat. No. : ADAMTS4-536H
Description : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Source : Wheat germ
Molecular Mass : 37.84 kDa
Sequence : RKFRYGYNNVVTIPAGATHILVRQQ GNPGHRSIYLALKLPDGSYALNGEY TLMPSPTDVVLPGAVSLRYSGATAA SETLSGHGPLAQPLTLQVLVAGNPQ DTRLRYSFFV
Storagebuffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Applications : ELISA; WB
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note : Best use within three months from the date of receipt of this protein.
OfficialSymbol : ADAMTS4
Gene Name : ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ]
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC 3.4.24.82
Gene ID : 9507
mRNA Refseq : NM_005099
Protein Refseq : NP_005090
MIM : 603876
UniProt ID : O75173
Chromosome Location : 1q21-q23
Pathway : Endochondral Ossification
Function : metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; protein binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is ADAMTS4 secreted by? 09/11/2022

ADAMTS4 is an inflammatory factor secreted by macrophages.

What is the relationship between ADAMTS4 and IL-1β? 12/01/2021

IL-1β can induce ADAMTS4 expression.

Where is ADAMTS4 expressed? 04/10/2021

ADAMTS4 is expressed in the heart, joint tissues, lungs, and other sites.

What is the biological function of ADAMTS4? 01/02/2021

ADAMTS4 is involved in the degradation of multifunctional proteoglycans in the vascular wall.

What diseases is ADAMTS4 used to study? 10/19/2020

ADAMTS4 could be used in research into diseases such as colorectal and gastric cancer.

Customer Reviews (3)

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Reviews
09/05/2021

    Professional personnel to provide after-sales service, experimental results are guaranteed.

    10/21/2020

      High protein concentration, good quality, worth buying.

      08/21/2019

        The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

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