Active Native Bovine HMGB1
Cat.No. : | HMGB1-8447B |
Product Overview : | Native Bovine HMGB1 was purified from Calf Thymus. |
- Specification
- Gene Information
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Description : | High mobility group 1 (HMG1) is a 26 kDa highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80–90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by directly contacting with distinct cellular proteins . HMG-1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG-1 is a late mediator of delayed endotoxin lethality by activating downstream cytokine release. |
Source : | Calf Thymus |
Species : | Bovine |
Tag : | N/A |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 10-100 units are required for a gel mobility shift assay in a 20μl reaction to super-shift TBP-DNA complex, 50-500 units are required for a reconstituted transcription assay and 100 units are sufficient for a protein-protein interaction assay. |
AA Sequence : | MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEEEEE DDDDE |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 900 μg/ml |
Shipping : | Dry Ice |
Gene Name : | HMGB1 high mobility group box 1 [ Bos taurus ] |
Official Symbol : | HMGB1 |
Synonyms : | HMGB1; high mobility group box 1; high mobility group protein B1; HMG-1; high mobility group protein 1 |
Gene ID : | 282691 |
mRNA Refseq : | NM_176612 |
Protein Refseq : | NP_788785 |
UniProt ID : | 10103 |
Chromosome Location : | chromosome: 12 |
Pathway : | Androgen Receptor Signaling Pathway, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem |
Function : | DNA binding, bending; chemoattractant activity; damaged DNA binding; double-stranded DNA binding |
Products Types
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HMGB1-965H | Recombinant Human HMGB1 Protein, His-tagged | +Inquiry |
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HMGB1-335C | Recombinant Cynomolgus Monkey HMGB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HMGB1-1677MCL | Recombinant Mouse HMGB1 cell lysate | +Inquiry |
HMGB1-2076HCL | Recombinant Human HMGB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThis protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.
Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.
Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.
HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.
HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.
The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.
Customer Reviews (3)
Write a reviewBroad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.
I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.
The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.
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