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Recombinant Mouse Ptpn6, His-GST tagged

Cat.No. : Ptpn6-8685M
Product Overview : Recombinant Mouse Ptpn6 (P29351-2) (Ala207-Lys597), fused with the N-terminal polyhistidine-tagged GST tag, was produced in Baculovirus-Insect cells.
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  • Gene Information
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Source : Baculovirus-Insect cells
Species : Mouse
Tag : His-GST
Predicted N Terminal : Met
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerolNormally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant mouse PTPN6/GST chimera consists of 628 amino acids and has a calculated molecular mass of 72.7 kDa. The recombinant protein migrates as an approximately 63 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >85 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Ptpn6 protein tyrosine phosphatase, non-receptor type 6 [ Mus musculus ]
Official Symbol : Ptpn6
Gene ID : 15170
mRNA Refseq : NM_001077705
Protein Refseq : NP_001071173

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PTPN6 function as a negative regulator in immune cells? 09/13/2022

PTPN6 acts as a phosphatase, removing phosphate groups from specific tyrosine residues in signaling molecules, thereby downregulating immune cell activation.

Can PTPN6 be a potential target for immunotherapy? 08/04/2020

Yes, PTPN6 modulation is being explored as a potential target for immunotherapies aimed at enhancing or suppressing immune responses based on the clinical context.

How does PTPN6 impact T cell signaling, and why is this important in clinical contexts? 09/09/2018

PTPN6 negatively regulates T cell receptor signaling, and its modulation can have implications in controlling excessive immune responses seen in autoimmune diseases.

Are there specific diseases where the clinical application of PTPN6 is being investigated? 10/02/2017

Yes, PTPN6 is being studied in diseases like rheumatoid arthritis, lupus, and certain types of leukemia and lymphoma.

In what ways can PTPN6 be targeted for therapeutic interventions? 08/24/2016

Researchers are exploring small molecule inhibitors and gene therapies to modulate PTPN6 activity, with potential applications in autoimmune disorders and cancer treatment.

Customer Reviews (3)

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Reviews
07/01/2020

    Structural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.

    04/03/2018

      PTPN6 protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.

      12/07/2017

        PTPN6 protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.

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