Native Human ACHE

• Cat.No.: ACHE-8345H
• Product Overview: Native Human ACHE was purified from Human erythrocytes.

Specification

• Description: Acetylcholinesterase (AChE) is involved in cholinergic transmission, where it catalyses the hydrolysis of the neurotransmitter acetylcholine. A membrane-bound protein on the post-synaptic membrane. Also found in some non-neuronal cells, such as erythrocytes where its function is unclear. The erythrocyte enzyme extracted from the membrane anchor, using Triton-X 100, has a molecular weight 160,000. AChE is the target the organophosphorus insecticides such as parathion and malathion, all of which irreversibly inhibit the enzyme. Depressed levels of AChE activity is a sensitive indicator of exposure to these agents. It is also the target of anti-Alzheimer""s drrugs such as tacrine, which are reversible inhibitors of the enzyme. Raised levels of AChE in amniotic fluid are indicative of foetal neural tube defects.
• Source: Human erythrocytes
• Species: Human
• Unit Definition: One unit will hydrolyse one micromole of Acetylthiocholine Iodide per minute at 37°C and pH 7.4.
• Concentration: >450 U/mg

Gene Information

• Gene Name: ACHE acetylcholinesterase [ Homo sapiens ]
• Official Symbol: ACHE
• Synonyms: ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE
• Gene ID: 43
• mRNA Refseq: NM_000665
• Protein Refseq: NP_000656
• MIM: 100740
• UniProt ID: P22303
• Chromosome Location: 7q22
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem
• Function: acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein homodimerization activity; protein self-association; serine hydrolase activity