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Active Recombinant Mouse Mrc1

Cat.No. : Mrc1-12M
Product Overview : Recombinant Mouse Mrc1(Leu19-Ala1388), fused with a C-terminal 6-His tag, was expressed in Mouse NSO Cells.
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  • Gene Information
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Description : The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity.
Source : Mammalian cells
Species : Mouse
Predicted N Terminal : Leu19
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its ability to bind with Mannan in a functional ELISA.
Molecular Mass : The recombinant Mouse Mrc1 predicts a molecular mass of 156 kDa (monomer). It migrates as an approximately 180 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 0.10 eu per 1 μg of the protein by the lal
Purity : >90%, by SDS-PAGE
Storage : Store it under sterile conditions at -20℃ to -70℃. It is recommended that the protein be aliquoted for optimal storage.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : MRC1 mannose receptor, C type 1 [ Homo sapiens ]
Official Symbol : Mrc1
Synonyms : MRC1; mannose receptor, C type 1; mannose receptor, C type 1 like 1 , MRC1L1; macrophage mannose receptor 1; bA541I19.1; CD206; CLEC13D; CLEC13DL; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1; MMR; MRC1L1; MGC181940;
Gene ID : 4360
mRNA Refseq : NM_002438
Protein Refseq : NP_002429
MIM : 153618
UniProt ID : P22897
Chromosome Location : 10p13
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem; Immune System, organism-specific biosystem; Phagosome, organism-specific biosystem;
Function : binding; mannose binding; receptor activity; sugar binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the main functions of MRC1 in the immune system? 09/27/2021

The primary function of MRC1 in the immune system is to recognize and bind mannose on the cell walls of bacteria and fungi, thereby limiting the growth and spread of these pathogens. It is also involved in regulating the activation and phagocytosis of macrophages.

Is there a correlation between MRC1 expression level and disease? 07/26/2021

Studies have shown that the expression level of MRC1 is associated with certain infectious diseases, inflammatory diseases, and autoimmune diseases. The high expression of MRC1 may enhance the phagocytosis and killing ability of macrophages and help control infection. However, low expression of MRC1 may affect the activation and function of macrophages, leading to disease progression.

Is there a relationship between the structure and function of MRC1? 07/02/2021

The structure of MRC1 determines its ability to recognize and bind mannose, and where and how it interacts with proteins such as TLR2 and TLR4. The study of its structure can help us understand its function and mechanism of action.

Does MRC1 play a role in lung infections? 09/18/2020

In lung infections, MRC1 may control the progression of lung infections by recognizing and binding to inhaled mannose, triggering an inflammatory response and activation of macrophages. It could be a potential target for the treatment of lung infections.

Does MRC1 interact with other proteins? 09/03/2020

MRC1 can interact with a variety of other proteins, including TLR2, TLR4, etc. These interactions allow it to recognize and bind to mannose and trigger an inflammatory response and activation of macrophages.

What are the treatment strategies for MRC1? 02/15/2020

Therapeutic strategies for MRC1 can include regulating its expression level, enhancing its ability to recognize and bind mannose, and promoting macrophage activation and phagocytosis. These methods may have potential applications in the treatment of infectious diseases, inflammatory diseases and autoimmune diseases.

Customer Reviews (3)

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Reviews
08/30/2023

    With MRC1, the reproducibility of Western blot was significantly improved.

    12/02/2022

      It can enhance the effectiveness of the body's immune response.

      01/12/2021

        It has high biological activity and stability.

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