| Description : |
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. The IL6 receptor is composed of two different subunits, IL6R that binds IL6 with low affinity, and ubiquitously expressed Glycoprotein 130 (gp130) which acts as a common signal-transducing receptor and binds the IL-6·IL-6R complex with high affinity. The IL6R, also known as CD126, is a type I transmembrane cytokine receptor and lacks a tyrosine/kinase domain within the cytoplasmic region, unlike other growth factor receptors. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. |
| Source : |
HEK293 |
| Species : |
Macaca mulatta |
| Tag : |
His |
| Form : |
Lyophilized. 25 mM Tris-HCl, pH7.4, 300 mM NaCl, 1 mM DTT, 5%Trehalose |
| Molecular Mass : |
The soluble form of recombinant Cynomolgus IL6R consists of 358 amino acids and has a predicted molecular mass of 40kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 60-65 kDa due to glycosylation. |
| AA Sequence : |
MLAVGCALLAALLATPGAALAPGGC PAQEVARGVLTSLPGDSVTLTCPGG EPEDNATVHWVLRKPAEGSHLSRWA GVGRRLLLRSVQLHDSGNYSCYRAG RPAATVHLLVDVPPEEPQLSCFRKS PLSNVVCEWGPRSTPSPTTKAVLLV RKFQNSPAEDFQEPCQYSQESQKFS CQLAVPEGDSSFYIVSMCVASSVGS KLSKTQTFQGCGILQPDPPANITVT AVARNPRWLSVTWQDPHSWNSSFYR LRFELRYRAERSKTFTTWMVKDLQH HCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAEN EVSTPTQAPTTNKDDDNILSGDSAN ATSLPVQD |
| Purity : |
>90% as determined by SDS-PAGE |
| Storage : |
Store it at +4℃ for short term. For long term storage, store it at -20℃ ～ -70℃ |
| Reconstitution : |
It is recommended to reconstitute the lyophilized Cynomolgus CD126 in 0.1ml sterile and pre-cooled ddH2O, which can then be further diluted to other aqueous solutions. |
