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Recombinant Mouse Kcnj6 (consisting of residues 52-380, constitutively active mutant)

Cat.No. : Kcnj6-9171M
Product Overview : Recombinant Mouse Kcnj6 (consisting of residues 52-380 , constitutively active mutant), was expressed in Pichia pastoris and purified by Affinity chromatography, Superdex-200 gel filtration.
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Description : Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.
Source : Pichia pastoris
Species : Mouse
Form : 20 mM Tris-HCl (pH 7.5), 150 mM KCl, 0.2% (w/v) DM ,20 mM DTT, and 1 mM EDTA
Molecular Mass : Predicts a molecular mass of 37KDa. As a result of transmembrane protein, it migrates approximately 33~40 KDa in SDS-PAGE under non-reducing conditions.
Protein length : 329 amino acids(residues 52-380)
Purity : >95% as determined by SDS-PAGE
Storage : Can be stored at +4℃ short term. For long term storage, store at -20℃
Concentration : 0.54 mg/ml
Gene Name : Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Mus musculus ]
Official Symbol : Kcnj6
Synonyms : KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6; G protein-activated inward rectifier potassium channel 2; GIRK-2; inward rectifier K(+) channel Kir3.2; potassium inwardly-rectifying channel J6; potassium channel, inwardly rectifying subfamily J member 6; wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
Gene ID : 16522
mRNA Refseq : NM_001025584
Protein Refseq : NP_001020755
Pathway : Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem;
Function : G-protein activated inward rectifier potassium channel activity; G-protein alpha-subunit binding; inward rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity;

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