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Recombinant Human PTPRN

Cat.No. : PTPRN-01H
Product Overview : Recombinant Human PTPRN protein, a DNA sequence encoding the amino acid (605-979) was expressed in E. coli and purified by Affinity chromatography, RT-HPLC.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Form : 1×PBS
Molecular Mass : 42.3kDa
AA Sequence : RQQDKERLAALGPEGAHGDTTFEYQ DLCRQHMATKSLFNRAEGPPEPSRV SSVSSQFSDAAQASPSSHSSTPSW CEEPAQANMDISTGHMILAYMEDHL RNRDRLAKEWQALCAYQAEPNTCAT AQGEGNIKKNRHPDFLPYDHARIK LKVESSPSRSDYINASPIIEHDPRM PAYIATQGPLSHTIADFWQMVWESG CTVIVMLTPLVEDGVKQCDRYWPD EGASLYHVYEVNLVSEHIWCEDFLV RSFYLKNVQTQETRTLTQFHFLSWP AEGTPASTRPLLDFRRKVNKCYRG RSCPIIVHCSDGAGRTGTYILIDMV LNRMAKGVKEIDIAATLEHVRDQRP GLVRSKDQFEFALTAVAEEVNAILK ALPQ
Endotoxin : <1.0eu g purified protein (lal>
Purity : >99% as determined by RT-HPLC
Storage : Can be stored at +4℃ short term (1-2 weeks). For long term storage, store at -20℃ or -70℃
Gene Name : PTPRN protein tyrosine phosphatase, receptor type, N [ Homo sapiens ]
Official Symbol : PTPRN
Synonyms : PTPRN; protein tyrosine phosphatase, receptor type, N; receptor-type tyrosine-protein phosphatase-like N; IA 2; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP; FLJ16131;
Gene ID : 5798
mRNA Refseq : NM_001199763
Protein Refseq : NP_001186692
MIM : 601773
UniProt ID : Q16849
Chromosome Location : 2q35-q36.1
Pathway : Type I diabetes mellitus, organism-specific biosystem; Type I diabetes mellitus, conserved biosystem;
Function : GTPase binding; hydrolase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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