| Description : |
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Supplied as lyophilized powder or solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, pH7.4. |
| Molecular Mass : |
The Predicted molecular weight is ~17kDa. It migrates as an approximately 19kDa band in SDS-PAGE under reducing conditions. |
| Purity : |
Greater than 95% as determined by SDS-PAGE |
| Storage : |
Can be stored at 4℃ short term (1-2 weeks). For long term storage, store at -70℃ for up to twelve months from date of receipt. Avoid repeated freeze-thaw cycles. |
| Reconstitution : |
It is recommended to reconstitute the lyophilized Mouse rMOG in sterile and pre-cooled ddH2O not less than 0.1mg/ml, which can then be further diluted to other aqueous solutions. |
