Recombinant Human IL7 protein
Cat.No. : | IL7-64H |
Product Overview : | Recombinant Human IL7 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-7 (IL-7) is encoded by the IL7 gene and secreted by stromal cells in the red marrow and thymus. It binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and also stimulates proliferation of B cells, T cells and NK cells. Murine IL-7 has approximately 65 % amino acid sequence identity with human IL-7 and both proteins exhibit cross-speciesactivity. IL-7 as an immunotherapy agent has been examinedin many human clinical trials for various malignancies and during HIV infection. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine 2E8 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 10⁶ IU/mg. |
Molecular Mass : | Approximately 17.4 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids. |
Protein length : | 152 |
AA Sequence : | DCDIEGKDGKQYESVLMVSIDQLLD SMKEIGSNCLNNEFNFFKRHICDAN KEGMFLFRAARKLRQFLKMNSTGDF DLHLLKVSEGTTILLNCTGQVKGRK PAALGEAQPTKSLEENKSLKEQKKL NDLCFLKRLLQEIKTCWNKILMGTK EH |
Endotoxin : | Less than 1 EU/µg of rHuIL-7 as determined by LAL method. |
Purity : | >97% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | IL7 |
Official Symbol : | IL7 |
Synonyms : | IL7; interleukin 7; interleukin-7; IL 7; IL-7; |
Gene ID : | 3574 |
mRNA Refseq : | NM_000880 |
Protein Refseq : | NP_000871 |
MIM : | 146660 |
UniProt ID : | P13232 |
Products Types
◆ Recombinant Protein | ||
IL7-2172M | Recombinant Mouse IL7 Protein | +Inquiry |
IL7-22H | Recombinant Human IL7 Protein, His-tagged | +Inquiry |
IL7-3155H | Recombinant Human IL7 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL7-215H | Recombinant Human IL7 Protein, His-tagged(C-ter) | +Inquiry |
IL7-518H | Recombinant Human IL7 Protein | +Inquiry |
◆ Lysates | ||
IL7-5223HCL | Recombinant Human IL7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.
IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.
The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.
It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.
Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.
This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.
Customer Reviews (3)
Write a reviewEffective in signal transduction pathway.
IL7 has good absorbability and high bioavailability.
Good stability under different environmental conditions
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