Recombinant Human ADRM1, His-tagged
Cat.No. : | ADRM1-15838H |
Product Overview : | Recombinant human ADRM1 protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
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- Gene Information
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Description : | ADRM1, also known as proteasomal ubiquitin receptor ADRM1, functions as a proteasomal ubiquitin receptor. This protein is an integral plasma membrane protein which promotes cell adhesion. ADRM1 is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT |
Molecular Mass : | 44.7 kDa (431aa) confirmed by MALDI-TOF |
Protein length : | 1-407aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMTTSGA LFPSLVPGSR GASNKYLVEF RAGKMSLKGT TVTPDKRKGL VYIQQTDDSL IHFCWKDRTS GNVEDDLIIF PDDCEFKRVP QCPSGRVYVL KFKAGSKRLF FWMQEPKTDQ DEEHCRKVNE YLNNPPMPGA LGASGSSGHE LSALGGEGGLQSLLGNMSHS QLMQLIGPAG LGGLGGLGAL TGPGLASLLG SSGPPGSSSS SSSRSQSAAV TPSSTTSSTR ATPAPSAPAA ASATSPSPAP SSGNGASTAA SPTQPIQLSD LQSILATMNV PAGPAGGQQV DLASVLTPEI MAPILANADV QERLLPYLPS GESLPQTADE IQNTLTSPQFQQALGMFSAA LASGQLGPLM CQFGLPAEAV EAANKGDVEA FAKAMQNNAK PEQKEGDTKD KKDEEEDMSL D |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1mg/ml (determined by Bradford assay) |
Gene Name : | ADRM1 adhesion regulating molecule 1 [ Homo sapiens ] |
Official Symbol : | ADRM1 |
Synonyms : | ADRM1; adhesion regulating molecule 1; proteasomal ubiquitin receptor ADRM1; ARM1; GP110; Rpn13; ARM-1; hRpn13; rpn13 homolog; M(r) 110,000 surface antigen; adhesion-regulating molecule 1; regulatory particle non-ATPase 13; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13; MGC29536; |
Gene ID : | 11047 |
mRNA Refseq : | NM_175573 |
Protein Refseq : | NP_783163 |
MIM : | 610650 |
UniProt ID : | Q16186 |
Chromosome Location : | 20q13.33 |
Function : | endopeptidase activator activity; protease binding; proteasome binding; protein binding; |
Products Types
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ADRM1-204R | Recombinant Rat ADRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADRM1-4385H | Recombinant Human ADRM1 protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
ADRM1-8996HCL | Recombinant Human ADRM1 293 Cell Lysate | +Inquiry |
ADRM1-8997HCL | Recombinant Human ADRM1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe expression level of ADRM1 protein is regulated at the transcriptional and post-transcriptional levels by various cellular factors.
Post-translational modifications, including phosphorylation and ubiquitination, have been identified on ADRM1 protein, which can modulate its stability and function.
ADRM1 protein is primarily involved in the regulation of protein degradation through the ubiquitin-proteasome system.
ADRM1 protein interacts with ubiquitinated proteins, serving as a receptor to deliver them to the proteasome for degradation.
Some pharmacological agents, such as proteasome inhibitors, can affect the activity of ADRM1 protein indirectly by modulating the overall proteasome function. However, specific small molecules targeting ADRM1 directly are currently under investigation.
Dysregulation of ADRM1 protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
Genetic and epigenetic factors can influence the expression and activity of ADRM1 protein, although specific regulatory mechanisms are still being elucidated.
Various experimental techniques, such as protein-protein interaction assays, immunoprecipitation, and mass spectrometry, have been used to study the function of ADRM1 protein.
ADRM1 protein is mainly localized to the cytoplasm and is associated with the 26S proteasome.
Yes, ADRM1 protein can interact with other proteins and participate in protein complexes involved in protein degradation processes.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in viral infections.
Detecting protein-protein interactions in multiprotein complexes.
Understanding protein-protein interaction networks in chromatin remodeling.
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