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Recombinant Human ADRM1, His-tagged

Cat.No. : ADRM1-15838H
Product Overview : Recombinant human ADRM1 protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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Description : ADRM1, also known as proteasomal ubiquitin receptor ADRM1, functions as a proteasomal ubiquitin receptor. This protein is an integral plasma membrane protein which promotes cell adhesion. ADRM1 is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Molecular Mass : 44.7 kDa (431aa) confirmed by MALDI-TOF
Protein length : 1-407aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMTTSGA LFPSLVPGSR GASNKYLVEF RAGKMSLKGT TVTPDKRKGL VYIQQTDDSL IHFCWKDRTS GNVEDDLIIF PDDCEFKRVP QCPSGRVYVL KFKAGSKRLF FWMQEPKTDQ DEEHCRKVNE YLNNPPMPGA LGASGSSGHE LSALGGEGGLQSLLGNMSHS QLMQLIGPAG LGGLGGLGAL TGPGLASLLG SSGPPGSSSS SSSRSQSAAV TPSSTTSSTR ATPAPSAPAA ASATSPSPAP SSGNGASTAA SPTQPIQLSD LQSILATMNV PAGPAGGQQV DLASVLTPEI MAPILANADV QERLLPYLPS GESLPQTADE IQNTLTSPQFQQALGMFSAA LASGQLGPLM CQFGLPAEAV EAANKGDVEA FAKAMQNNAK PEQKEGDTKD KKDEEEDMSL D
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : ADRM1 adhesion regulating molecule 1 [ Homo sapiens ]
Official Symbol : ADRM1
Synonyms : ADRM1; adhesion regulating molecule 1; proteasomal ubiquitin receptor ADRM1; ARM1; GP110; Rpn13; ARM-1; hRpn13; rpn13 homolog; M(r) 110,000 surface antigen; adhesion-regulating molecule 1; regulatory particle non-ATPase 13; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13; MGC29536;
Gene ID : 11047
mRNA Refseq : NM_175573
Protein Refseq : NP_783163
MIM : 610650
UniProt ID : Q16186
Chromosome Location : 20q13.33
Function : endopeptidase activator activity; protease binding; proteasome binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is the expression level of ADRM1 protein regulated under normal physiological conditions? 09/16/2022

The expression level of ADRM1 protein is regulated at the transcriptional and post-transcriptional levels by various cellular factors.

Are there any known post-translational modifications of ADRM1 protein and how do they affect its function? 04/21/2022

Post-translational modifications, including phosphorylation and ubiquitination, have been identified on ADRM1 protein, which can modulate its stability and function.

What are the specific cellular processes or pathways in which ADRM1 protein is involved? 03/09/2021

ADRM1 protein is primarily involved in the regulation of protein degradation through the ubiquitin-proteasome system.

What are the downstream targets or substrates of ADRM1 protein, and what are the consequences of their interaction? 08/28/2020

ADRM1 protein interacts with ubiquitinated proteins, serving as a receptor to deliver them to the proteasome for degradation.

Are there any pharmacological agents or small molecules that can modulate the activity or expression of ADRM1 protein? 08/04/2017

Some pharmacological agents, such as proteasome inhibitors, can affect the activity of ADRM1 protein indirectly by modulating the overall proteasome function. However, specific small molecules targeting ADRM1 directly are currently under investigation.

How does ADRM1 protein contribute to the development or progression of specific diseases or disorders? 06/06/2017

Dysregulation of ADRM1 protein has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.

Are there any genetic or epigenetic factors that influence the expression or activity of ADRM1 protein? 01/25/2017

Genetic and epigenetic factors can influence the expression and activity of ADRM1 protein, although specific regulatory mechanisms are still being elucidated.

What experimental techniques have been used to study the function of ADRM1 protein? 10/02/2016

Various experimental techniques, such as protein-protein interaction assays, immunoprecipitation, and mass spectrometry, have been used to study the function of ADRM1 protein.

Can ADRM1 protein be localized to specific cellular compartments or structures? 04/05/2016

ADRM1 protein is mainly localized to the cytoplasm and is associated with the 26S proteasome.

Can ADRM1 protein interact with other proteins or participate in protein complexes? 01/25/2016

Yes, ADRM1 protein can interact with other proteins and participate in protein complexes involved in protein degradation processes.

Customer Reviews (3)

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Reviews
09/16/2017

    Exploring protein-protein interactions involved in viral infections.

    03/09/2017

      Detecting protein-protein interactions in multiprotein complexes.

      01/28/2017

        Understanding protein-protein interaction networks in chromatin remodeling.

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