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Recombinant Human ABHD2, GST-tagged

Cat.No. : ABHD2-9240H
Product Overview : Recombinant human ABHD2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.
Source : E.coli
Species : Human
Tag : GST
Protein length : C-term-301a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ABHD2 abhydrolase domain containing 2 [ Homo sapiens ]
Official Symbol : ABHD2
Synonyms : ABHD2; abhydrolase domain containing 2; abhydrolase domain-containing protein 2; LABH2; protein PHPS1-2; lung alpha/beta hydrolase 2; alpha/beta hydrolase domain containing protein 2; HS1-2; PHPS1-2; MGC26249; MGC111112;
Gene ID : 11057
mRNA Refseq : NM_007011
Protein Refseq : NP_008942
MIM : 612196
UniProt ID : P08910
Chromosome Location : 15q26.1
Function : carboxylesterase activity; hydrolase activity; molecular_function;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Where does the ABHD2 express in mouse? Any function in mouse? 01/10/2022

Tthe mouse ABHD2 is expressed in vascular smooth muscle cells (SMCs) and that enhanced migration occurs with cultured vascular SMCs from Abhd2-deficient mice. Enhanced neointimal hyperplasia was observed in ABHD2-deficient mice.

Where does the ABHD2 express strongly? 10/05/2021

This protein is strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg.

Is there any bioloical application of ABHD2 membrane protein? 08/31/2021

Yes. Endogenous steroids and plant triterpenoids can influence CatSper activation via modulation of ABHD2.

What kind of biological techique can be used to identify inhibitors for ABHD2? 11/29/2020

A gel-based assay using MB064 was employed to identify novel inhibitors for ABHD2.

What is the biological function of the ABHD2 protein in the presence of progesterone (or Pregnenolone Sulfate)? 10/30/2019

In the presence of Progesterone (or Pregnenolone Sulfate) it cleaves 2-arachidonoylglycerol (2AG) into glycerol and arachidonic acid (AA). 2AG inhibits sperm calcium channel CatSper, and so when ABHD2 removes 2AG calcium flows into the cell through the CatSper channel, leading to hyperactivation. ABHD2 is inhibited by testosterone, (as well as hydrocortisone, and the plant triterpenoids lupeol and pristimerin) which may prevent premature hyperactivation.

How does the ABHD2 gene influence the ovaria? 07/28/2019

Suppression of ABHD2 may promote a malignant phenotype and poor prognosis for women with serous ovarian cancer.

How to prove the ABHD2 play a important role in accelerating proliferation of cancer cells? 07/12/2019

The human ABHD2 protein sequence shows an α/β hydrolase domain with conserved GXSXG lipase motif. To study the role of this conserved GXSXG domain, ABHD2 was cloned, overexpressed and the recombinant protein was used for in vitro enzyme assays. The results obtained with His-tag purified recombinant ABHD2 protein clearly displayed both TAG lipase and ester hydrolase activities.

What is the role of ABHD2 in human disease? 08/19/2018

The ABHD2 gene is down regulated in the lungs of people with Emphysema. ABHD2 is important in maintaining the structural integrity of the lungs, and that disruption of phospholipid metabolism in the alveoli may lead to the development of emphysema. Increased expression has also been seen in the lungs of smokers.

Is there any association of ABHD2 expression and clinicopathological factors in the high-grade serous ovarian cancer? 05/30/2018

The prognosis of the low-ABHD2 group patients was significantly worse as compared to that of the high group patients

Are these any other co-gene affect the resistance of anoikis, simiar as the ABHD2? 05/11/2018

By performing a functional genomics screen using an shRNA library to search for drivers of anoikis resistance in high-grade serous ovarian cancer, we can successfully identified three genes, ABHD2, ELAC2 and CYB5R3 whose downregulation increased resistance to anoikis.

Customer Reviews (5)

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01/11/2021

    I have never in my life received products so quickly following my order!

    10/29/2020

      Great performance in ELISA.

      04/29/2020

        Good product.It is a first choice.

        11/30/2019

          This antibody works very well for our samples.

          04/24/2019

            This product provide detailed instructions, including application, storage condition, etc. Love it!

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