Recombinant Human ABL2, His-tagged

• Cat.No.: ABL2-9250H
• Product Overview: Recombinant Human ABL2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 822-1167a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 [ Homo sapiens ]
• Official Symbol: ABL2
• Synonyms: ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2; ABLL, v abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson related gene); Abelson tyrosine-protein kinase 2; Abelson related gene; ARG; tyrosine-protein kinase ARG; abelson-related gene protein; ABLL
• Gene ID: 27
• mRNA Refseq: NM_001136000
• Protein Refseq: NP_001129472
• MIM: 164690
• UniProt ID: P42684
• Chromosome Location: 1q25.2
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem; Signaling by Robo receptor, organism-specific biosystem; Viral myocarditis, organism-specific biosystem
• Function: ATP binding; actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activit