Recombinant Human AMELX, GST-tagged
Cat.No. : | AMELX-9612H |
Product Overview : | Recombinant Human AMELX protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 25-191a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | AMELX amelogenin, X-linked [ Homo sapiens ] |
Official Symbol : | AMELX |
Synonyms : | AMELX; amelogenin, X-linked; AIH1, amelogenin (X chromosome, amelogenesis imperfecta 1) , AMG; amelogenin, X isoform; amelogenesis imperfecta 1; amelogenin (amelogenesis imperfecta 1, X-linked); amelogenin (X chromosome, amelogenesis imperfecta 1); AMG; AI1E; AIH1; ALGN; AMGL; AMGX; |
Gene ID : | 265 |
mRNA Refseq : | NM_001142 |
Protein Refseq : | NP_001133 |
MIM : | 300391 |
UniProt ID : | Q99217 |
Chromosome Location : | Xp22.31-p22.1 |
Function : | cell surface binding; growth factor activity; hydroxyapatite binding; identical protein binding; protein binding; structural constituent of tooth enamel; structural constituent of tooth enamel; |
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◆ Lysates | ||
AMELX-70HCL | Recombinant Human AMELX cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMELX undergoes various post-translational modifications, including phosphorylation and glycosylation, which contribute to its proper folding, secretion, and enamel matrix assembly.
AMELX gene regulation during tooth development is orchestrated by a complex interplay of transcription factors, epigenetic modifications, and signaling pathways, ensuring precise spatiotemporal expression for enamel formation.
AMELX contributes to the mechanical properties of enamel, such as its hardness, resilience, and wear resistance, through its involvement in enamel crystal organization and interlocking.
Manipulating AMELX expression or activity holds potential for enamel regeneration strategies, such as promoting ameloblast differentiation from stem cells or developing biomimetic materials that mimic the composition and structure of natural enamel for tooth repair and restoration.
Mutations or deletions in the AMELX gene result in amelogenesis imperfecta, leading to enamel defects, such as hypoplasia or hypomineralization, and compromised tooth integrity.
AMELX interacts with other enamel matrix proteins, such as amelogenin and enamelin, as well as extracellular matrix components, facilitating enamel matrix assembly, organization, and mineralization.
Signaling pathways, including Wnt, BMP, and FGF signaling, regulate AMELX expression and function, coordinating ameloblast differentiation, enamel secretion, and mineralization processes.
AMELX is highly expressed in ameloblasts, the cells responsible for enamel formation, and its role involves the synthesis and secretion of enamel matrix proteins essential for enamel structure and hardness.
AMELX plays a critical role in enamel mineralization by participating in the nucleation and growth of hydroxyapatite crystals, influencing their size, orientation, and arrangement within the enamel matrix.
AMELX expression may change during tooth aging or in dental diseases, reflecting altered enamel turnover, enamel remineralization processes, or adaptive responses to pathological conditions.
Customer Reviews (3)
Write a reviewPrecise quantification of protein expression changes in disease states.
Reduced assay background noise for improved signal-to-noise ratio.
Wide range of available detection methods for versatility.
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