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Recombinant Human BCCIP, GST-tagged

Cat.No. : BCCIP-10171H
Product Overview : Recombinant Human BCCIP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-314a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : BCCIP BRCA2 and CDKN1A interacting protein [ Homo sapiens ]
Official Symbol : BCCIP
Synonyms : BCCIP; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BCCIPalpha; TOK 1; BCCIPbeta; TOK-1beta; TOK-1alpha; protein TOK-1; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; BRCA2 and Cip1/p21 interacting protein; TOK1; TOK-1;
Gene ID : 56647
mRNA Refseq : NM_016567
Protein Refseq : NP_057651
MIM : 611883
UniProt ID : Q9P287
Chromosome Location : 10q26.2
Function : kinase regulator activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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