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Recombinant Human CADM2, His-tagged

Cat.No. : CADM2-10652H
Product Overview : Recombinant Human CADM2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : 28-404a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CADM2 cell adhesion molecule 2 [ Homo sapiens ]
Official Symbol : CADM2
Synonyms : CADM2; cell adhesion molecule 2; IGSF4D, immunoglobulin superfamily, member 4D; Necl 3; NECL3; nectin like 3; SynCAM2; nectin-like 3; nectin-like protein 3; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4D; IGSF4D; Necl-3; synCAM2; MGC104534; MGC138341; MGC138343;
Gene ID : 253559
mRNA Refseq : NM_001167674
Protein Refseq : NP_001161146
MIM : 609938
UniProt ID : Q8N3J6
Chromosome Location : 3p12.2
Pathway : Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CADM2 contribute to tissue-specific adhesion and recognition in the immune system, and what implications does this have for vaccine development or immunotherapy? 08/31/2022

CADM2's role in immune cell adhesion and recognition is relevant to vaccine development and immunotherapy strategies, as it influences immune cell interactions and responses.

How does CADM2's expression change during development, and what are its roles in tissue development and differentiation? 10/02/2021

CADM2 expression varies during development and contributes to tissue development and cellular differentiation, particularly in the nervous system

Can you explain the significance of CADM2 in neural cell adhesion and synaptic plasticity, particularly in the context of neurological disorders? 07/15/2020

CADM2 is essential for neural cell adhesion and synaptic plasticity, contributing to the formation and maintenance of neural connections. Dysregulation of CADM2 has been linked to neurological disorders like schizophrenia and autism spectrum disorders.

How does CADM2 contribute to immune responses, and what is its role in autoimmune diseases or cancer immunology? 04/23/2019

CADM2 plays a role in immune cell interactions and modulates immune responses. Its involvement in autoimmune diseases and cancer immunology is an area of ongoing research.

What are the known post-translational modifications of CADM2, and how do they influence its function in cellular adhesion and signaling pathways? 12/06/2018

Post-translational modifications, such as phosphorylation and glycosylation, modulate CADM2's interactions and functions, affecting cellular adhesion and signaling pathways.

Customer Reviews (3)

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11/09/2021

    This is hands down the best product I've ever tried.

    06/29/2020

      It's made a significant difference in my workouts and recovery time.

      04/17/2019

        I've been using the product for a few months now, and it has exceeded my expectations.

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