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Recombinant Human CALB1, His-tagged

Cat.No. : CALB1-10656H
Product Overview : Recombinant Human CALB1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted.
Source : E.coli
Species : Human
Tag : His
Protein length : 109-262a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CALB1 calbindin 1, 28kDa [ Homo sapiens ]
Official Symbol : CALB1
Synonyms : CALB1; calbindin 1, 28kDa; CALB; calbindin; D-28K; calbindin D28; RTVL-H protein; calbindin 1, (28kD); vitamin D-dependent calcium-binding protein, avian-type;
Gene ID : 793
mRNA Refseq : NM_004929
Protein Refseq : NP_004920
MIM : 114050
UniProt ID : P05937
Chromosome Location : 8p11
Pathway : Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem;
Function : calcium ion binding; vitamin D binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there specific brain regions or cell types where CALB1 is particularly abundant? 02/02/2021

CALB1 is highly expressed in specific populations of neurons, such as Purkinje cells in the cerebellum and certain interneurons in the cortex and hippocampus.

How does CALB1 contribute to neuronal excitability and synaptic transmission at the molecular level? 10/11/2020

CALB1 can influence neuronal excitability by buffering calcium ions and modulating the activity of calcium-dependent signaling pathways, which can impact synaptic transmission and plasticity.

What is the role of CALB1 in intracellular calcium homeostasis within neurons? 03/15/2019

CALB1 helps maintain precise calcium concentrations in neuronal compartments, ensuring proper calcium signaling and preventing calcium-induced cell damage.

What are the consequences of CALB1 deficiency or dysregulation at the molecular level? 12/08/2018

CALB1 dysregulation can disrupt calcium homeostasis, leading to altered neuronal signaling, impaired synaptic plasticity, and increased susceptibility to excitotoxicity.

How does CALB1 bind calcium ions at the molecular level? 06/20/2018

CALB1 possesses EF-hand calcium-binding motifs that undergo conformational changes upon calcium binding, allowing it to tightly and specifically bind calcium ions.

Customer Reviews (3)

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07/23/2021

    Ready-to-use proteins save time on sample preparation.

    11/30/2020

      Reliable purity minimizes experimental variability.

      04/02/2020

        These proteins are indispensable tools for research success.

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