Recombinant Human CASP1, GST-tagged
Cat.No. : | CASP1-10729H |
Product Overview : | Recombinant Human CASP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-311a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | CASP1 caspase 1, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Official Symbol : | CASP1 |
Synonyms : | CASP1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis related cysteine peptidase (interleukin 1, beta, convertase) , caspase 1, apoptosis related cysteine protease (interleukin 1, beta, convertase) , IL1BC; caspase-1; caspase 1; ICE; interleukin 1; beta; convertase; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); P45; IL1BC; |
Gene ID : | 834 |
mRNA Refseq : | NM_001223 |
Protein Refseq : | NP_001214 |
MIM : | 147678 |
UniProt ID : | P29466 |
Chromosome Location : | 11q23 |
Pathway : | Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; |
Function : | cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; peptidase activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
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CASP1-0411H | Recombinant Human CASP1 Protein, GST-Tagged | +Inquiry |
CASP1-1266H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged | +Inquiry |
CASP1-621H | Recombinant Human CASP1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CASP1-7840HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
CASP1-7841HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt processes pro-inflammatory cytokines to their active forms, modulating inflammation.
Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).
It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.
CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.
Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.
Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.
CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.
Customer Reviews (3)
Write a reviewFast delivery, reliable results.
Very high-quality product.
Great for protein research.
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