Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CASP1, GST-tagged

Cat.No. : CASP1-10729H
Product Overview : Recombinant Human CASP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-311a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CASP1 caspase 1, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP1
Synonyms : CASP1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis related cysteine peptidase (interleukin 1, beta, convertase) , caspase 1, apoptosis related cysteine protease (interleukin 1, beta, convertase) , IL1BC; caspase-1; caspase 1; ICE; interleukin 1; beta; convertase; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); P45; IL1BC;
Gene ID : 834
mRNA Refseq : NM_001223
Protein Refseq : NP_001214
MIM : 147678
UniProt ID : P29466
Chromosome Location : 11q23
Pathway : Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
Function : cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; peptidase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CASP1 contribute to the regulation of the inflammatory response? 08/06/2022

It processes pro-inflammatory cytokines to their active forms, modulating inflammation.

What therapeutic strategies are being explored targeting CASP1 for disease treatment? 02/13/2022

Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).

What role does CASP1 play in the maturation and secretion of pro-inflammatory cytokines? 06/07/2021

It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.

In which cells or tissues is CASP1 predominantly expressed? 09/30/2019

CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.

Are there known genetic mutations in CASP1 associated with specific diseases? 09/09/2019

Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.

How is CASP1 implicated in the pathogenesis of autoinflammatory diseases? 04/03/2019

Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.

What is the primary biological function of CASP1 in cells? 07/26/2018

CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.

Customer Reviews (3)

Write a review
Reviews
09/14/2022

    Fast delivery, reliable results.

    01/21/2022

      Very high-quality product.

      07/28/2021

        Great for protein research.

        Ask a Question for All CASP1 Products

        Required fields are marked with *

        My Review for All CASP1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends