Recombinant Human CCDC134, GST-tagged

• Cat.No.: CCDC134-10789H
• Product Overview: Recombinant Human CCDC134 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-229a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CCDC134 coiled-coil domain containing 134 [ Homo sapiens ]
• Official Symbol: CCDC134
• Synonyms: CC134_HUMAN; ccdc134; coiled-coil domain containing 134; Coiled-coil domain-containing protein 134; dJ821D11.3; FLJ22349; MGC21013; CCDC134
• Gene ID: 79879
• mRNA Refseq: NM_024821.2
• Protein Refseq: NP_079097.1
• UniProt ID: Q9H6E4
• Chromosome Location: 22q13.2