Recombinant Human CST3, GST-tagged

• Cat.No.: CST3-11643H
• Product Overview: Recombinant Human CST3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 25-146a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CST3 cystatin C [ Homo sapiens ]
• Official Symbol: CST3
• Synonyms: CST3; cystatin C; cystatin C (amyloid angiopathy and cerebral hemorrhage); cystatin-C; cystatin 3; cystatin-3; gamma-trace; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide; ARMD11; MGC117328
• Gene ID: 1471
• mRNA Refseq: NM_000099
• Protein Refseq: NP_000090
• MIM: 604312
• UniProt ID: P01034
• Chromosome Location: 20p11.2
• Pathway: Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; Salivary secretion, organism-specific biosystem; Salivary secretion, conserved biosystem
• Function: beta-amyloid binding; cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protease binding; protein binding