Recombinant Human DUSP12, His-tagged
Cat.No. : | DUSP12-12205H |
Product Overview : | Recombinant Human DUSP12 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-340a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | DUSP12 dual specificity phosphatase 12 [ Homo sapiens ] |
Official Symbol : | DUSP12 |
Synonyms : | DUSP12; dual specificity phosphatase 12; dual specificity protein phosphatase 12; DUSP1; serine/threonine specific protein phosphatase; YVH1; YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; |
Gene ID : | 11266 |
mRNA Refseq : | NM_007240 |
Protein Refseq : | NP_009171 |
MIM : | 604835 |
UniProt ID : | Q9UNI6 |
Chromosome Location : | 1q21-q22 |
Function : | hydrolase activity; kinase binding; metal ion binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
Dusp12-2681M | Recombinant Mouse Dusp12 Protein, Myc/DDK-tagged | +Inquiry |
DUSP12-1632R | Recombinant Rat DUSP12 Protein, His (Fc)-Avi-tagged | +Inquiry |
DUSP12-01H | Recombinant Human DUSP12 Protein, Myc/DDK-tagged | +Inquiry |
DUSP12-794H | Recombinant Human DUSP12 Protein, His (Fc)-Avi-tagged | +Inquiry |
DUSP12-2925H | Recombinant Human DUSP12 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
DUSP12-6782HCL | Recombinant Human DUSP12 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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