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Recombinant Human FSHR, His-tagged

Cat.No. : FSHR-13016H
Product Overview : Recombinant Human FSHR protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
Source : E.coli
Species : Human
Tag : His
Protein length : 18-352a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : FSHR follicle stimulating hormone receptor [ Homo sapiens ]
Official Symbol : FSHR
Synonyms : FSHR; follicle stimulating hormone receptor; ODG1; follicle-stimulating hormone receptor; FSHRO; LGR1; FSH receptor; follitropin receptor; MGC141667; MGC141668;
Gene ID : 2492
mRNA Refseq : NM_000145
Protein Refseq : NP_000136
MIM : 136435
UniProt ID : P23945
Chromosome Location : 2p21-p16
Pathway : Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Hormone ligand-binding receptors, organism-specific biosystem;
Function : follicle-stimulating hormone receptor activity; peptide hormone binding; protein binding; receptor activity; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which FSHR modulates bone density and the risk of osteoporosis? 02/27/2022

FSHR regulates bone density, with implications for osteoporosis risk, particularly post-menopause.

How do alterations in FSHR expression or signaling affect hormone replacement therapies? 04/30/2021

Changes in FSHR signaling can influence the efficacy and outcomes of hormone replacement therapies.

How does FSHR (Follicle Stimulating Hormone Receptor) regulate ovarian follicle development and ovulation in females? 03/19/2021

FSHR is key in stimulating ovarian follicle growth and triggering ovulation in women.

What role does FSHR play in spermatogenesis and male fertility? 03/06/2021

FSHR plays a significant role in male fertility, essential for the process of spermatogenesis.

What is the impact of FSHR mutations on fertility and the development of reproductive disorders? 01/13/2021

Mutations in FSHR can lead to fertility issues and reproductive disorders in both sexes.

How does FSHR influence hormonal regulation and menstrual cycle in women? 01/29/2020

FSHR affects hormonal balance and menstrual cycle regulation in females.

How does FSHR contribute to the pathogenesis of polycystic ovary syndrome (PCOS)? 02/23/2019

FSHR is involved in PCOS pathogenesis, potentially affecting ovarian function and hormone levels.

Customer Reviews (3)

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05/16/2021

    Exceptional protein expression optimization support, highly appreciated assistance.

    02/11/2021

      Accurate protein structural analysis, indispensable for our investigations.

      10/05/2020

        Timely antibody validation, an invaluable asset for our laboratory.

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