Recombinant Human GABRA5, GST-tagged

• Cat.No.: GABRA5-13095H
• Product Overview: Recombinant Human GABRA5 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 356-423a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 [ Homo sapiens ]
• Official Symbol: GABRA5
• Synonyms: GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor; alpha 5; GABA(A) receptor, alpha 5; GABA(A) receptor subunit alpha-5; MGC138184
• Gene ID: 2558
• mRNA Refseq: NM_000810
• Protein Refseq: NP_000801
• MIM: 137142
• UniProt ID: P31644
• Chromosome Location: 15q12
• Pathway: GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity; transporter activity