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Recombinant Human GGPS1, GST-tagged

Cat.No. : GGPS1-13243H
Product Overview : Recombinant Human GGPS1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-300a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ]
Official Symbol : GGPS1
Synonyms : GGPS1; geranylgeranyl diphosphate synthase 1; geranylgeranyl pyrophosphate synthase; GGPPS1; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase; GGPPS;
Gene ID : 9453
mRNA Refseq : NM_001037277
Protein Refseq : NP_001032354
MIM : 606982
UniProt ID : O95749
Chromosome Location : 1q43
Pathway : Cholesterol biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Terpenoid backbone biosynthesis, organism-specific biosystem; Terpenoid backbone biosynthesis, conserved biosystem; geranylgeranyldiphosphate biosynthesis, organism-specific biosystem;
Function : dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does GGPS1 play in protein prenylation? 12/28/2022

GGPS1 is involved in protein prenylation, essential for the function of many proteins.

How does GGPS1 interact with other enzymes in cholesterol metabolism? 02/25/2022

GGPS1 works in tandem with other enzymes involved in cholesterol and lipid metabolism.

How do genetic variations in GGPS1 affect its enzymatic activity? 12/22/2020

Genetic mutations in GGPS1 can lead to changes in lipid metabolism and synthesis.

What is the impact of altered GGPS1 activity on lipid synthesis? 11/18/2019

Altered GGPS1 activity affects the production of important lipid compounds, impacting cell function.

How does GGPS1 contribute to cholesterol biosynthesis? 05/13/2018

It plays a role in cholesterol biosynthesis by providing precursors necessary for the process.

What is the primary role of GGPS1 in cellular metabolism? 02/12/2018

GGPS1, Geranylgeranyl Pyrophosphate Synthase 1, is crucial for synthesizing geranylgeranyl pyrophosphate, a key intermediate in lipid metabolism.

What potential therapeutic applications arise from targeting GGPS1? 10/08/2017

Targeting GGPS1 offers potential treatments for disorders related to lipid metabolism.

Customer Reviews (3)

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09/23/2021

    Key contributor to discoveries. Valuable research partner.

    01/29/2020

      Trusted for research integrity. Supports our projects effectively.

      06/08/2019

        Efficient and dependable. Elevates our research standards.

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