Recombinant Human GGPS1, GST-tagged
Cat.No. : | GGPS1-13243H |
Product Overview : | Recombinant Human GGPS1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]). |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-300a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ] |
Official Symbol : | GGPS1 |
Synonyms : | GGPS1; geranylgeranyl diphosphate synthase 1; geranylgeranyl pyrophosphate synthase; GGPPS1; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase; GGPPS; |
Gene ID : | 9453 |
mRNA Refseq : | NM_001037277 |
Protein Refseq : | NP_001032354 |
MIM : | 606982 |
UniProt ID : | O95749 |
Chromosome Location : | 1q43 |
Pathway : | Cholesterol biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Terpenoid backbone biosynthesis, organism-specific biosystem; Terpenoid backbone biosynthesis, conserved biosystem; geranylgeranyldiphosphate biosynthesis, organism-specific biosystem; |
Function : | dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGGPS1 is involved in protein prenylation, essential for the function of many proteins.
GGPS1 works in tandem with other enzymes involved in cholesterol and lipid metabolism.
Genetic mutations in GGPS1 can lead to changes in lipid metabolism and synthesis.
Altered GGPS1 activity affects the production of important lipid compounds, impacting cell function.
It plays a role in cholesterol biosynthesis by providing precursors necessary for the process.
GGPS1, Geranylgeranyl Pyrophosphate Synthase 1, is crucial for synthesizing geranylgeranyl pyrophosphate, a key intermediate in lipid metabolism.
Targeting GGPS1 offers potential treatments for disorders related to lipid metabolism.
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