Recombinant Human GLO1, GST-tagged
Cat.No. : | GLO1-13304H |
Product Overview : | Recombinant Human GLO1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-184a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | GLO1 glyoxalase I [ Homo sapiens ] |
Official Symbol : | GLO1 |
Synonyms : | GLO1; glyoxalase I; lactoylglutathione lyase; GLOD1; glyoxalase domain containing 1; glx I; aldoketomutase; methylglyoxalase; ketone-aldehyde mutase; lactoyl glutathione lyase; S-D-lactoylglutathione methylglyoxal lyase; GLYI; |
Gene ID : | 2739 |
mRNA Refseq : | NM_006708 |
Protein Refseq : | NP_006699 |
MIM : | 138750 |
UniProt ID : | Q04760 |
Chromosome Location : | 6p21.3-p21.1 |
Pathway : | Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism, conserved biosystem; methylglyoxal degradation I, organism-specific biosystem; |
Function : | lactoylglutathione lyase activity; lyase activity; metal ion binding; |
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◆ Lysates | ||
GLO1-5899HCL | Recombinant Human GLO1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGLO1 is implicated in diabetes and metabolic disorders, influencing glycation end products and insulin signaling.
GLO1 modulates cancer cell growth and spread, affecting tumor development and metastasis.
GLO1 works with the glyoxalase system to regulate cellular detoxification and protect against metabolic stress.
GLO1 expression affects cellular oxidative stress, playing a role in aging and age-related cellular damage.
Genetic variations in GLO1 alter its activity, affecting disease risk and response to metabolic stress.
Changes in GLO1 levels impact neurological function and may contribute to the progression of neurodegenerative diseases.
GLO1 detoxifies methylglyoxal and other aldehydes, preventing cellular damage and maintaining metabolic balance.
Customer Reviews (3)
Write a reviewTimely protein expression optimization; improves our research efficiency.
Accurate protein structural analysis; crucial for our studies.
Dependable antibody validation; boosts our immunoprecipitation studies.
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