Recombinant Human GMNN, GST-tagged

• Cat.No.: GMNN-13336H
• Product Overview: Recombinant Human GMNN protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-209a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: GMNN geminin, DNA replication inhibitor [ Homo sapiens ]
• Official Symbol: GMNN
• Synonyms: GMNN; geminin, DNA replication inhibitor; geminin; Gem
• Gene ID: 51053
• mRNA Refseq: NM_001251989
• Protein Refseq: NP_001238918
• MIM: 602842
• UniProt ID: O75496
• Chromosome Location: 6p21.32
• Pathway: Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication, organism-specific biosystem
• Function: histone deacetylase binding; protein binding; repressing transcription factor binding