Recombinant Human IDO1, GST-tagged
Cat.No. : | IDO1-14054H |
Product Overview : | Recombinant Human IDO1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-403a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens ] |
Official Symbol : | IDO1 |
Synonyms : | IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1; |
Gene ID : | 3620 |
mRNA Refseq : | NM_002164 |
Protein Refseq : | NP_002155 |
MIM : | 147435 |
UniProt ID : | P14902 |
Chromosome Location : | 8p12-p11 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem; |
Function : | electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; tryptophan 2,3-dioxygenase activity; |
Products Types
◆ Recombinant Protein | ||
IDO1-2645R | Recombinant Rat IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDO1-4414M | Recombinant Mouse IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IDO1-1419H | Recombinant Human IDO1 Protein (1-403 aa), His-tagged | +Inquiry |
IDO1-2077M | Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged | +Inquiry |
IDO1-085H | Recombinant Human IDO1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1763 | IDO1 Inhibitor Mechanism of Action Assay Kit | +Inquiry |
Kit-2211 | Indoleamine 2,3-Dioxygenase 1 Activity Assay Kit | +Inquiry |
Kit-1756 | Human IDO1 Fluorogenic Inhibitor Screening Assay Kit (384) | +Inquiry |
Kit-1782 | Mouse IDO1 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewThe product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.
Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.
The purchased proteins helped me to get satisfactory experimental results.
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