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Recombinant Human IDO1, GST-tagged

Cat.No. : IDO1-14054H
Product Overview : Recombinant Human IDO1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-403a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens ]
Official Symbol : IDO1
Synonyms : IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1;
Gene ID : 3620
mRNA Refseq : NM_002164
Protein Refseq : NP_002155
MIM : 147435
UniProt ID : P14902
Chromosome Location : 8p12-p11
Pathway : African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem;
Function : electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; tryptophan 2,3-dioxygenase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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08/12/2022

    The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

    05/14/2022

      Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.

      03/12/2022

        The purchased proteins helped me to get satisfactory experimental results.

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