Recombinant Human IKBKB, GST-tagged
Cat.No. : | IKBKB-14132H |
Product Overview : | Recombinant Human IKBKB protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-256a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ] |
Official Symbol : | IKBKB |
Synonyms : | IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK beta; IKK2; IKKB; NFKBIKB; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; IKK-beta; FLJ33771; FLJ36218; FLJ38368; FLJ40509; MGC131801; |
Gene ID : | 3551 |
mRNA Refseq : | NM_001190720 |
Protein Refseq : | NP_001177649 |
MIM : | 603258 |
UniProt ID : | O14920 |
Chromosome Location : | 8p11.2 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; |
Function : | ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; |
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Ikbkb-1232M | Recombinant Mouse Ikbkb Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
IKBKB-849HCL | Recombinant Human IKBKB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionIKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.
Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.
IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.
Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.
Customer Reviews (3)
Write a reviewTheir team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.
Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.
This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.
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