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Recombinant Human KEAP1, Gly & Pro tagged

Cat.No. : KEAP1-550H
Product Overview : Recombinant Human KEAP1 (Q14145) (Gln2-Cys624), fused with two additional amino acids (Gly & Pro) at the N-terminus, was produced in Baculovirus-Insect cells.
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  • Gene Information
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Source : Baculovirus-Insect cells
Species : Human
Tag : Gly & Pro
Predicted N Terminal : Gly
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant human KEAP1 consists of 625 amino acids and predicts a molecular mass of 69.7 KDa. The apparent molecular mass of the protein is approximately 64 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >90 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : KEAP1 kelch-like ECH-associated protein 1 [ Homo sapiens ]
Official Symbol : KEAP1
Gene ID : 9817
mRNA Refseq : NM_012289
Protein Refseq : NP_036421
MIM : 606016
UniProt ID : Q14145
Chromosome Location : 19p13.2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does KEAP1 function in the body's defense against oxidative stress? 12/22/2021

KEAP1 acts as a sensor for oxidative stress by interacting with NRF2. When cells experience oxidative stress, KEAP1 releases NRF2, allowing it to translocate into the nucleus and initiate the expression of various cytoprotective genes.

How is the interaction between KEAP1 and NRF2 regulated within cells? 08/23/2018

Post-translational modifications such as phosphorylation, ubiquitination, and acetylation control the interaction between KEAP1 and NRF2, influencing NRF2's stability and activity.

Are there any challenges in targeting KEAP1 for therapeutic interventions? 01/25/2018

One challenge is the need for specific targeting without causing adverse effects on normal cell function, as NRF2 has both protective and potentially harmful effects.

In what other ways can the KEAP1 protein be targeted for therapeutic purposes? 09/01/2017

Researchers are exploring small molecules that modulate the KEAP1-NRF2 interaction, aiming to enhance NRF2 activation for therapeutic benefit in conditions where oxidative stress plays a significant role.

Are there ongoing clinical trials involving KEAP1-related therapies? 07/03/2016

Yes, there are clinical trials investigating drugs that target the KEAP1-NRF2 pathway in cancer treatment, especially for lung and pancreatic cancers.

Customer Reviews (3)

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Reviews
01/02/2023

    This protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.

    06/29/2016

      KEAP1 protein has proven to be instrumental in protein electron microscopy structure analysis.

      04/07/2016

        With KEAP1 protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.

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