Active Recombinant Human PADI4, His-tagged
Cat.No. : | PADI4-380H |
Product Overview : | Recombinant Human PADI4 (Ala2-Pro663) fused with an N-terminal 11 kDa fusion protein, a thrombin cleavage linker and 6His tag at Cterminal, was expressed in E. coli. |
- Specification
- Gene Information
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Description : | This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Inconclusive result, Met predicted. Protein identity confirmed by MS analysis of tryptic fragments |
Formulation : | Supplied as a 0.2 µm filtered solution in Sodium Acetate, NaCl, DTT, EDTA and Glycerol. |
Bio-activity : | Measured by its ability to catalyze the deimination of benzoyl-arginine ethyl ester. The specific activity is >1000 pmol/min/µg, as measured under the described conditions. |
Molecular Mass : | Predicted Molecular Mass: 87 kDa SDS-PAGE: 75-85 kDa, reducing conditions |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. |
Storage : | Avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening. |
Gene Name : | PADI4 peptidyl arginine deiminase, type IV [ Homo sapiens (human) ] |
Official Symbol : | PADI4 |
Synonyms : | PADI4; PAD; PAD4; PDI4; PDI5; PADI5; peptidyl arginine deiminase, type IV; protein-arginine deiminase type-4; HL-60 PAD; PADI-H protein; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V; EC 3.5.3.15 |
Gene ID : | 23569 |
mRNA Refseq : | NM_012387 |
Protein Refseq : | NP_036519 |
MIM : | 605347 |
UniProt ID : | Q9UM07 |
Chromosome Location : | 1p36.13 |
Pathway : | protein citrullination |
Function : | calcium ion binding; protein-arginine deiminase activity |
Products Types
◆ Recombinant Protein | ||
PADI4-001H | Recombinant Human PADI4 Protein, His/GST-tagged | +Inquiry |
PADI4-0219H | Recombinant Human PADI4 Protein (A2-P663), His tagged | +Inquiry |
Padi4-038M | Recombinant Mouse Padi4 Protein, His-tagged | +Inquiry |
PADI4-203H | Recombinant Human PADI4 Protein, MYC/DDK-tagged | +Inquiry |
PADI4-1599H | Recombinant Human PADI4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PADI4-630HCL | Recombinant Human PADI4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (7)
Ask a questionPADI4 is predominantly expressed in various tissues, including synovial tissues, immune cells, and certain epithelial cells.
PADI4 plays a crucial role in citrullination, a process that converts arginine residues to citrulline, influencing protein structure and function.
Peptidyl arginine deiminase 4 (PADI4) primarily functions in cellular processes, contributing to the post-translational modification of proteins through citrullination.
In the regulation of immune responses, PADI4 is implicated in autoimmune diseases such as rheumatoid arthritis, where it contributes to autoantibody generation.
Dysregulation or abnormal expression of PADI4 is associated with autoimmune disorders, particularly rheumatoid arthritis.
There are potential therapeutic implications related to targeting PADI4 in autoimmune disorders, making it a focus for drug development.
Specific substrates of PADI4 include histones and other proteins, impacting cellular processes like gene regulation and signaling pathways.
Customer Reviews (3)
Write a reviewThe minimal variation across different batches enhanced the repeatability of our results.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.
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