Recombinant human NRG4, His-tagged
Cat.No. : | NRG4-2472H |
Product Overview : | Recombinant human NRG4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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- Gene Information
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Description : | NRG4 belongs to the neuregulin family and contains 1 EGF-like domain. The protein is low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl(pH8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT |
Molecular Mass : | 9.1kDa (84aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name : | NRG4 neuregulin 4 [ Homo sapiens ] |
Official Symbol : | NRG4 |
Synonyms : | NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944; |
Gene ID : | 145957 |
mRNA Refseq : | NM_138573 |
Protein Refseq : | NP_612640 |
MIM : | 610894 |
UniProt ID : | Q8WWG1 |
Chromosome Location : | 15q23 |
Pathway : | ErbB receptor signaling network, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, conserved biosystem; ErbB4 signaling events, organism-specific biosystem; GRB2 events in ERBB2 signaling, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; |
Function : | growth factor activity; |
Products Types
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Nrg4-1861R | Recombinant Rat Nrg4 Protein, His-tagged | +Inquiry |
NRG4-825H | Recombinant Human NRG4 Protein, His-tagged | +Inquiry |
NRG4-167 | Recombinant NRG4 Protein, GST-tagged | +Inquiry |
Nrg4-366M | Recombinant Mouse Nrg4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.
It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.
In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.
Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.
NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.
The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.
Customer Reviews (3)
Write a reviewNRG4 had the intended biological effect in the experiment.
The experimental results using NRG4 are accurate and reliable, and the data are scientific.
NRG4's products have been widely recognized and applied in the research of related fields.
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